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Read moreEvolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series
https://www.sciencedirect.com/science/article/pii/S0022283609015381?via%3Dihub
The evolution of multiple active site configurations in a designed enzyme
https://www.nature.com/articles/s41467-018-06305-y
HMMer notes, avoid redundant searching